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International Congress on Engineering Technologies (EngiTek 2022)
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  • EngiTek 2020
  • 51.Cnf-1117
EngiTek Congresses with Published Papers
EngiTek 2020, Irbid
2
Papers Published at EngiTek 2020
All 2 Papers
IDAuthors and TitlePages
51.Cnf-17 Mr. Ameer Mubaslat
Mr. Ahmad Al Haj
Prof. Saud Khashan
Simulation assisted leak detection in pressurized systems using machine learning
1-6
51.Cnf-1062 Dr. Aqeed M. Chyad
Dr. Osama Abudayyeh
Dr. Maha Alkasisbeh
A Nonlinear Regression-Based Machine Learning Model for Predicting Concrete Bridge Deck Condition
7-11
51.Cnf-1117 Paper View Page
Title Streamline Development of Propellent-Free Topical Pharmaceutical Foam Via Quality by Design Approach for Potential Sunscreen Application
Authors Dr. Esraa Albarahmieh, German-Jordanian University, Amman, Jordan
Ms. Razan Al Ziadat, German-Jordanian University, Amman, Jordan
Prof. Munib Saket, German-Jordanian University, Amman, Jordan
Dr. Mohammad Khanfar, German-Jordanian University, Amman, Jordan
Dr. Walid Al-Zyoud, German-Jordanian University, Amman, Jordan
Abstract Catching up with a recent interest in developing green pharmaceutical products, a key challenge is encountering formulation scientists to find proper ingredients, approach or dispensing tools in a reasonable time due to manufacturing variability. Therefore, this work is established to produce green propellent-free topical pharmaceutical preparation and thus environmentally friendly, through utilization of the concept of quality by design (QbD) to eliminate or reduce the source of variability. A foam dosage form with ingredients suitable for potential sunscreen application was developed. Formulation ingredients were based on local Jordanian virgin olive oil. Twenty formulae were screened under the theme of QbD. One formulation successfully combined in relatively stable water in oil emulsion, whereby foam generation was achieved through specialized dispensing tool. Textural characteristics were evaluated by human panel (30) and found favourably acceptable for this formulation. Physicochemical characteristics of the investigated and optimized formulae were confirmed through light microscopy, viscosity and spectrophotochemical measurements. Sun protection factor (SPF) was determined as 12.1±0.6 (n=3); indicating potential sunscreen applications for almost two hours in the daytime. Critical quality attributes were determined throughout the development process and risk assessment measurements were estimated thereof. Such an outcome that will help to create preliminary predictive model for scalable industrial screening production of this green pharmaceutical topical preparation with local sourcing of generally regarded safe materials (GRAS).
Track MDM: Materials, Design and Manufacturing
Conference 1st International Conference on Mechanical Engineering and Technologies (MechaniTek 2020)
Congress International Congress on Engineering Technologies (EngiTek 2020), 16-18 June 2020 (Remotely), Irbid, Jordan
Pages --1
Topics Pharmaceutical Industry
Materials and Nanotechnology
ISSN 2227-331X
DOI
BibTeX @inproceedings{1117EngiTek2020,
title={Streamline Development of Propellent-Free Topical Pharmaceutical Foam Via Quality by Design Approach for Potential Sunscreen Application},
author={Esraa Albarahmieh, and Razan Al Ziadat, and Munib Saket, and Mohammad Khanfar, and Walid Al-Zyoud},
booktitle={International Congress on Engineering Technologies (EngiTek 2020)},
year={2020},
pages={--1},
doi={}},
organization={Mosharaka for Research and Studies} }
Paper Views 636 Paper Views Rank 87/525
Paper Downloads 229 Paper Downloads Rank 91/525
EngiTek 2020 Visits: 18520||MechaniTek 2020 Visits: 7462||MDM Track Visits: 1706