Simulation and Synthesis of Homogeneous Drug Encapsulating Nanoparticles
Authors
Dr. Ruba Khnouf, Jordan University of Science and Technology, Irbid, Jordan Ms. Ala'a Migdade, Jordan University of Science and Technology, Irbid, Jordan Ms. Esraa Alshawwa, Jordan University of Science and Technology, Irbid, Jordan
Abstract
Targeted cancer therapeutics delivery has been a challenge that has been under investigation for years, where the need for a delivery conduit that is small enough to accumulate in tumor cells while being biocompatible and in coherence with the drug’s chemistry has only increased. Polymer-based Nanocapsules have proven to be an attractive vehicle for targeted cancer therapies, however drug encapsulation using polymeric materials has been difficult in terms of maintaining a homogeneous capsule size distribution and the ability to efficiently load small Nanocapsules with drugs. It has been suggested and shown that the application of microfluidic devices in the high throughput- controlled synthesis of drug-loaded nanoparticles can overcome these obstacles. We employed a microfluidic system to synthesize homogenous polymeric nanoparticles (NPs) with controlled characteristics. We also demonstrated the effect of polymer concentration, flow rate ratio, and the flow rate of the aqueous phase on the NPs size. We finally simulated different similar conditions to better explain the observations made.
1st International Conference on Electrical Engineering and Technologies (ElectriTek 2020)
Congress
International Congress on Engineering Technologies (EngiTek 2020), 16-18 June 2020, Irbid, Jordan
Pages
--1
Topics
Bionanotechnology BioMEMS and Microfluidics
ISSN
2227-331X
DOI
BibTeX
@inproceedings{1131EngiTek2020,
title={Simulation and Synthesis of Homogeneous Drug Encapsulating Nanoparticles },
author={Ruba Khnouf, and Ala'a Migdade, and Esraa Alshawwa},
booktitle={International Congress on Engineering Technologies (EngiTek 2020)},
year={2020},
pages={--1},
doi={}},
organization={Mosharaka for Research and Studies}
}
